When a top-secret weapon is stolen from a U.S. defense contractor, CIA agent Colin Glass is paired with FBI agent Bill Goodman to investigate. Their partnership gets off to a rocky start, but they soon realize their opposing viewpoints may be their greatest asset.

When a known smuggler is flagged at the New York border with unidentified cargo, Colin and Bill head upstate to track. To find this smuggler, they must enlist the help of a foreign intelligence officer looking to defect.

When a deeply embedded U.S. intelligence officer is detained in Hong Kong, Nikki insists on traveling there to bring him home but her cover is blown.

When a wanted Belarusian national is discovered posing as an expecting father, Colin and Bill work to expose an international illegal baby smuggling ring.

After a cyber engineer and her family are killed in a targeted attack, Colin and Bill rush to stop the culprits before they strike again.

After Colin receives a tip on an upcoming terror plot, the team recovers a young man who was kidnapped nine years ago in Turkey and dig into his time in captivity to help stop the attack. Meanwhile, Bill looks into someone very close to Colin.

When handling security for an international soccer game, a bomb threat leads Colin and Bill to two players who are being hunted after they go missing. As the case evolves, the team leans on FBI's Special Agent in Charge Isobel Castille and Special Agent Maggie Bell for assistance.