The Substance

Overview

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Fun facts

Awards
Won 3 awards, including the Golden Globe for Best Actor: Motion Picture Musical or Comedy (2025) and the Best Screenplay Award (2024)
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Nominations
3 award nominations, including the Oscar for Best Picture (2025)
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Box office
Grossed $77.3M worldwide, about 4.4 times its $17.5M budget
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Filming locations
Filmed in Studios d'Épinay, Paris and Provence-Alpes-Côte d'Azur
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Inspired by
Inspired by The Fly, The Picture of Dorian Gray and Requiem for a Dream
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Setting
Set in Hollywood
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Music
Music by Raffertie
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Cinematography
Cinematography by Benjamin Kračun
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